The NISIR 2024 Booklet presents an overview of the National Institute for Scientific and Industrial Research (NISIR), a statutory body under the Ministry of Technology and Science of Zambia, mandated to conduct and promote scientific, technological, and industrial research for national development. The booklet highlights NISIR’s vision of providing sustainable socio-economic solutions through innovation and research, detailing its organizational structure, research centres, and key programmes. It covers major centres such as Materials Engineering and Technical Services, Energy Development Research, Digital Transformation and Strategic Information, Animal Science, Plant Science, Food Science, and Water and Environment Research. Each centre’s mandate, ongoing projects, and innovations—including renewable energy initiatives, biogas purification technologies, digital transformation, indigenous knowledge systems, GMO testing, and aflatoxin mitigation—are outlined to showcase the institute’s multidisciplinary contributions to national development. The document also emphasizes NISIR’s collaborations, capacity-building programmes, and alignment with Zambia’s 8th National Development Plan and the United Nations Sustainable Development Goals, reaffirming its pivotal role in advancing science, technology, and innovation for a sustainable and industrialized Zambia.